ABSTRACT
Background: The use of vaccines as preventive agents for SARS-CoV-2 infection has generated collateral effects, including arthralgias. The objective of this case report was to describe the treatment and evolution of a patient with arthralgia secondary to vaccination with BNT162b2 (Pfizer - BioNTech), with ozone and ozonized growth factors. Methods: The patient was a 53-year-old, white male with no medical history who had received 2 doses of the BNT162b2 vaccine, with an interval of 6 weeks. After the second dose, the patient reported the permanence of arthralgia in the fifth finger of the right hand, and the third finger of the left hand with an intensity of 9-10 on the visual analog scale (VAS) scale. The patient was locally infiltrated with ozone 6 mg/mL (intra articular and with the glove technique), twice a week for 2 weeks, and was subsequently treated with platelet-derived growth factor, Silfradent (R) CGF (Concentrated Grow Factors) activated with ozone, in a single session. Results: The patient evolved satisfactorily with a final VAS reduction to a value of 1-2 and reduction of clinical symptoms. Medical ozone and regenerative medicine using CGF, can represent a useful complement in mitigating collateral effects such as post-vaccination arthralgias. Conclusions: Larger clinical studies are needed to demonstrate its clinical efficacy in this indication.
ABSTRACT
Context: Currently, there is no effective antiviral therapy recommended for novel coronavirus pneumonia 2019 (COVID-19). Aims: To assess the safety of ozonized saline solution (O3SS) used as a complementary therapy in adult COVID-19 patients. Methods: Twenty-five adult patients hospitalized with mild to severe symptoms of COVID-19, who met the inclusion criteria and were treated from April 18 to April 26, 2020, at Virgen De La Paloma Hospital, Madrid, Spain were included in this study. Patients were assigned to receive standard care consisting ceftriaxone (250 mg – 2 g twice daily for 7 days) plus azithromycin (500 mg once daily for 5 days), of 200 - 400 mg hydroxychloroquine twice daily for 5-7 days plus tocilizumab 400 mg twice daily for 5 days, low molecular weight heparin and 40 to 60 mg metil-prednisone plus O3SS, 200 mL, 3-5 µg/mL per day for 10 days. No control group was included, the data was compared to clinical trials in this subject. Secondary endpoints assessed included the clinical status of participants, laboratory examinations, and duration of viral shedding. Results: Patients with COVID-19 with mild to severe symptoms who received intravenous O3SS as an adjunct treatment experienced no side effects. The main results of O3SS treatment were a tendency to improve clinical symptoms without side effects. None of the patients treated died. Conclusions: Early evidence of efficacy shown improvements in symptoms such as dyspnea, weakness, and reduction in body temperature were observed and corresponded to improvements in laboratory results including D-dimer, fibrinogen, lactate dehydrogenase, and C-reactive protein. These preliminary data will serve as the basis for a future study of the effectiveness of this therapy.